Nitazoxanide: A New Thiazolide Antiparasitic Agent
نویسندگان
چکیده
منابع مشابه
Nitazoxanide: a new thiazolide antiparasitic agent.
Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. At present, there are no documented drug-drug interactions. Nitazoxanide has been licensed for the treatment of Giardia intes...
متن کاملCORRESPONDENCE Nitazoxanide as a Broad-Spectrum Antiparasitic Agent To the Editor—In a randomized, double-blind, placebo-con-
To the Editor—In a randomized, double-blind, placebo-controlled study of nitazoxanide, Rossignol et al. [1] reported excellent therapeutic response in patients with diarrhea caused by Giardia intestinalis and Entamoeba histolytica and/or Entamoeba dispar infection. Earlier open-label clinical investigations of therapeutic response to nitazoxanide in 125 patients with Fasciola hepatica infection...
متن کاملAntiparasitic agent atovaquone.
Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There is also limited experience with other prot...
متن کاملEvaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum.
Thirty-nine new thiazolide/thiadiazolide compounds were compared with the nitrothiazole nitazoxanide for activity against Cryptosporidium parvum development in HCT-8 cells. Twenty-seven agents exerted > or =90% inhibition. Agents with a lower 50% inhibitory concentration (IC(50)) than nitazoxanide were either NO(2) or halogen 5 substituted on the thiazole moiety. Other 5 substitutions such as m...
متن کاملMining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads
The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors originally developed for the latter may be a source of promising lead compounds for the former. We describe h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2005
ISSN: 1058-4838,1537-6591
DOI: 10.1086/428839